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| Vertex Pharmaceuticals |
Cambridge |
MA |
9/8/2010
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| Head of Medicinal Chemistry |
| Possessing a Ph.D. in medicinal or synthetic chemistry, the Head of Medicinal Chemistry will most likely be currently leading a small to medium size chemistry domain in a large pharmaceutical or biotech company and will meet the following qualifications:
(a) Have a minimum of 10 years experience, as a member of a successful multidisciplinary R&D team in pharmaceutical drug discovery, with a demonstrated track record in the chemical design and synthesis, as well as biological characterization of drug candidates
(b) Have experience in successfully leading and managing a mid-size (minimally 15 scientists) group conducting drug discovery research, including leadership of strategic planning of chemical patent protection, construction and management of spending budgets for researchers.
(c) Possess an expert knowledge in the modern methods of synthetic and medicinal chemistry with proven ability to successfully and simultaneously conduct medicinal chemistry on multiple projects
(d) Possess a strong knowledge of computational chemistry methods and understanding of the target-based taxonomy of drug candidates as well as a solid working knowledge of biophysical methods such as: X-ray crystallography, macromolecular NMR, high-throughput screening as applied to drug discovery, and preferably how scale-up chemistry and formulations development are expedited for development candidates
(e) Command a solid grasp of cellular /molecular biology, biochemistry, disease pharmacology, mechanisms of drug metabolism and molecular toxicology, pharmaco-kinetic and pharmaco-dynamic sciences, and the evaluation of formulations for the in vivo evaluation of drug candidates
The Head of Medicinal Chemistry will be a dynamic and innovative scientist, with a well-developed sense of self-awareness, leadership and independence. Further, he or she will be an inspirational communicator, in written and verbal formats, with the demonstrated ability to instill vision for department, and collaborate effectively with counterparts in diverse domains such as biology, pharmacology, computational sciences and biophysics. As a vital part of Vertex? research management team, he or she will play a critical role in enabling the discovery goals of the research site.
Vertex Pharmaceuticals Incorporated is a global biotechnology company committed to the discovery and development of breakthrough small molecule drugs for serious diseases. The Company's strategy is to commercialize its products both independently and in collaboration with major pharmaceutical companies. Vertex's product pipeline is focused on viral diseases, cystic fibrosis, inflammation, autoimmune diseases, cancer, and pain.
Vertex Pharmaceuticals |
| Vertex Pharmaceuticals |
Cambridge |
MA |
9/8/2010
|
| Research Scientist II |
| The ideal candidate for this position will be highly motivated and minimally have an MS degree with at least 10 years, or a PhD or DVM with at least 8 years of hands-on experience in using relevant general/safety pharmacology assays, such as cardiovascular telemetry or Langendorff heart perfusion.
Extensive understanding of cardiovascular pharmacology and physiology is required. Demonstrated independent thinking, trouble-shooting skills, and ability to analyze, interpret, and translate physiological function data is a must. Industry non-clinical research experience and experience with assessing drug-induced QT prolongation is preferred. Extensive knowledge of Data Sciences International/Ponemah (P3P and DataQuest), EMKA Technologies, or similar software packages is necessary. Ability to write basic programs using SAS software for data analysis and statistics is a plus.
The candidate must be able to work independently and in a matrix and function team environment. Strong written and oral communication skills are required, including excellent report writing and presentation skills. Study outsourcing and/or supervisory experiences are a plus.
Vertex Pharmaceuticals Incorporated is a global biotechnology company committed to the discovery and development of breakthrough small molecule drugs for serious diseases. The Company's strategy is to commercialize its products both independently and in collaboration with major pharmaceutical companies. Vertex's product pipeline is focused on viral diseases, cystic fibrosis, inflammation, autoimmune diseases, cancer, and pain.
Vertex Pharmaceuticals |
| Vertex Pharmaceuticals |
Cambridge |
MA |
9/8/2010
|
| Medicinal Chemist/ Research Scientist I |
| This position requires a MS in Synthetic or Medicinal Chemistry and at least 3 years experience as a medicinal chemist in an industrial setting with a proven record of achievement or a PhD and a post doc in Synthetic or Medicinal Chemistry.
Excellent communication skills are required, as the successful candidate will be expected to interact with scientists in other disciplines on a daily basis. Experience with Structure based design a plus.
Vertex Pharmaceuticals Incorporated is a global biotechnology company committed to the discovery and development of breakthrough small molecule drugs for serious diseases. The Company's strategy is to commercialize its products both independently and in collaboration with major pharmaceutical companies. Vertex's product pipeline is focused on viral diseases, cystic fibrosis, inflammation, autoimmune diseases, cancer, and pain.
Vertex Pharmaceuticals |
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