Associate Principal Scientist, Flow Cytometry, Translational Molecular Biomarkers Job in New Jersey (NJ), Research and Development Career, Full Time Jobs in Merck & Co.
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Life Science Career Fair

Associate Principal Scientist, Flow Cytometry, Translational Molecular Biomarkers job in Rahway

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Merck & Co. jobs
New Jersey (NJ), Rahway
Job Code:  MERCUSR290984ENUS
Employer:  Merck & Co.
Category:  Research and Development
Job Type:  Full Time

Location
Country:  United States
State:  New Jersey (NJ)
City:  Rahway
04/19/2024

Description
Job Description

Translational Molecular Biomarkers (TMB) is responsible for translating preclinical molecular biomarkers to clinical development across all therapeutic areas and all phases of clinical development at our company's Research laboratories. TMB laboratories leverage a diverse array of technologies to develop biomarker assays to help confirm engagement of therapeutic targets, understand mechanisms drug action, and patient response.

The Flow Cytometry group within the TMB organization is seeking a highly motivated candidate to join our team. The individual will play a critical role in the development and validation of flow cytometric assays that are deployed in support of clinical trials. The candidate for this Associate Principal Scientist position should have strong technical and biological-area expertise in flow cytometry, immunology, oncology, cell biology, and molecular biology. The candidate should also have a strong interest in lab-based assay work. In addition, the successful candidate should have a desire to collaborate closely with out-sourcing partners on the scientific and technical oversight of flow cytometric assays that support our pipeline.

The individual will have the following responsibilities:
  • Lead in the transition of biomarker flow cytometry assays from Basic Research to Clinical Development.
    • Design, develop, and optimize flow cytometric assays for all therapeutic areas and all phases of clinical development.
    • Provide technical guidance on fit-for-purpose assay validation.
    • Troubleshoot assay and instrument-related issues.
  • Serve as a subject matter expert in flow cytometry by collaborating with project teams, biomarker leaders, clinical operations, regulatory affairs, scientists, and physicians to facilitate the successful implementation of these assays and execute on biomarker strategies in clinical trials across early and late-stage clinical development.
  • Liaise with external partners and Contract Research Organizations (CROs) to oversee the development and execution of flow cytometry assays.
  • Write memos, final reports and publications summarizing data, and write/update lab SOPs.

Education Minimum Requirement: -
  • BS, BA, MS, or Ph.D. in a life sciences discipline (Biochemistry, Immunology, Cell Biology, or related field.)

Required Experience and Skills**:
  • A minimum of 12+ (for BS or BA) or 8+ (for MS) or 5 (for PhD) years of clinical laboratory, academic laboratory, or pharmaceutical industry experience.
  • Strong understanding of translational medicine and biomarker development.
  • Extensive knowledge and experience in flow cytometry techniques including panel design, assay development, optimization, and validation, as well as instrument optimization, maintenance, and troubleshooting.
  • In-depth experience in data analysis and interpretation using relevant analytical software tools (i.e. OMIQ, FlowJo, FCS Express, etc.).
  • Proficient project management skills to effectively plan, coordinate, and prioritize activities to achieve project goals.
  • Strong interpersonal, verbal, and written communication skills.
  • Motivated and able to work independently with strong leadership skills.
  • Ability to execute within a matrixed organization and collaborate with cross-functional teams.

Preferred Experience and Skills:
  • Well-versed in the latest research, industry trends, and technological advancements.
  • Multi-color flow cytometry experience utilizing traditional and/or full spectrum cytometers (i.e. BD and Cytek flow cytometers).
  • Designing and developing the following flow cytometry assays:
  • Immunophenotyping
  • Minimal Residual Disease (MRD)
  • Receptor Occupancy
  • High-dimensional Flow Cytometry
  • TILs
  • Phospho-signaling
  • Intracellular Cytokine Profiling
  • Cellular Proliferation
  • Experience working with Contract Research Organizations (CROs) and possess strong skills in clear communication, detailed protocol transfer, quality agreements, regular updates, secure data transfer, regulatory compliance, and effective collaboration.
  • Handling primary cells derived from human tissues.
  • Primary cell isolation techniques such as tissue dissociation, density gradient centrifugation, magnetic bead separation, and/or fluorescence-activated cell sorting (FACS).
  • Establishing and maintaining cell cultures.
  • Performing in vitro/ex vivo differentiation and stimulation functional assays.
  • Providing training and mentorship.

NOTICE FOR INTERNAL APPLICANTS

In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.

#EligibleforERP

Employees working in roles that the Company determines require routine collaboration with external stakeholders, such as customer-facing commercial, or research-based roles, will be expected to comply not only with Company policy but also with policies established by such external stakeholders (for example, a requirement to be vaccinated against COVID-19 in order to access a facility or meet with stakeholders). -Please understand that, as permitted by applicable law, if you have not been vaccinated against COVID-19 and an essential function of your job is to call on external stakeholders who require vaccination to enter their premises or engage in face-to-face meetings, then your employment may pose an undue burden to business operations, in which case you may not be offered employment, or your employment could be terminated. Please also note that, where permitted by applicable law, the Company reserves the right to require COVID-19 vaccinations for positions, such as in Global Employee Health, where the Company determines in its discretion that the nature of the role presents an increased risk of disease transmission.

Current Employees apply HERE

Current Contingent Workers apply HERE

US and Puerto Rico Residents Only:

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.

We are an Equal Opportunity Employer, committed to fostering an inclusive and diverse workplace. - All qualified applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status, or other applicable legally protected characteristics. - For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:

EEOC Know Your Rights

EEOC GINA Supplement•

Pay Transparency Nondiscrimination

We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively.

Learn more about your rights, including under California, Colorado and other US State Acts

U.S. Hybrid Work Model

Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, generally Tuesday, Wednesday and either Monday or Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence. -This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as "remote".

Under New York State, Colorado State, Washington State, and California State law, the Company is required to provide a reasonable estimate of the salary range for this job. Final determinations with respect to salary will take into account a number of factors, which may include, but not be limited to the primary work location and the chosen candidate's relevant skills, experience, and education.

Expected salary range:
$122,800.00 - $193,300.00

Available benefits include bonus eligibility, health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and sick days. - For Washington State Jobs, a summary of benefits is listed here .

Search Firm Representatives Please Read Carefully-
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. -No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.-

Employee Status:
Regular

Relocation:
Domestic

VISA Sponsorship:
Yes

Travel Requirements:
10%

Flexible Work Arrangements:
Hybrid

Shift:
Not Indicated

Valid Driving License:
No

Hazardous Material(s):
Standard lab chemicals

Requisition ID:R290984
ref: (MERCUSR290984ENUS)
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