Associate Principal Scientist - Neuroscience (Boston) job in Boston
|Employer:|| Merck & Co.|
Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where Merck has codified its legacy for over a century . Merck's success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare. |
Merck is on a quest for cures and is committed to being the world's premier, most research-intensive biopharmaceutical company. Today, we're doubling down on this goal. Merck Research Laboratories is a true scientific research facility of tomorrow, and will take Merck's leading discovery capabilities and world-class small molecule and biologics R&D expertise to create breakthrough science that radically changes the way we approach serious diseases.
Merck's Boston-based discovery neuroscience team is seeking an experienced drug discoverer to join our team in the pursuit of disease modifying therapies for neurodegenerative diseases. This is an opportunity to become part of an established dynamic team focused on discovering therapies rationalized from human genetics, disease pathologies, innate immune biology and phenotyping of patient-derived cells and tissues. The successful candidate will oversee the development and validation of in vivo murine models that explore the spatial and temporal interactions of disease pathologies (e.g. -amyloid and tau), the response of the innate immune system and therapeutic interventions. They will also integrate and adapt learnings from in vivo and in vitro models to improve model validity. Demonstrated expertise in the application of pharmacology, cell biology, histology and biochemistry strategies and experience in both small molecule and biologics modalities is required. The candidate must be an effective communicator with a strong publication record in their area of expertise. This position is for a scientist who can lead by directly engaging with and enable their colleagues in the design, execution and understanding of experimental outcomes.
The responsibilities of the Discovery Neuroscience team member include:
• Develop validation strategies for improving disease relevant in vivo models
• Independently develop, execute, troubleshoot experiments and supervise others activities.
• Manage in depth pharmacological profiling of investigational small molecule and biologics therapies linking disease related endpoints to target PK/PD in chronic in vivo disease models.
• Communicate data clearly and concisely to teams and stakeholders.
• Monitor, review and critically interpret published work to guide internal research.
• Propose novel CNS targets and develop comprehensive target validation strategies
• Collaborate across functional areas, including medicinal chemistry, in vivo and in vitro pharmacology and translational sciences.
• Manage activities at external academic, biotechnology, and contract research organizations
EDUCATION and EXPERIENCE
• PhD in Pharmacology, Biochemistry, Neuroscience or related discipline with a minimum of 6 years of biotech or pharmaceutical industry experience are required.
• Established record of innovative thinking to champion new ideas and solve problems.
• Demonstrated ability to thrive in a team environment, manage colleagues and build a team.
• Thrives in the lab with expertise in molecular neuroscience techniques in vitro and in vivo including stereotactic injections, viral transduction, microdialysis, creation/management of transgenic mouse lines.
• Extensive experience with quantitative histological and biochemical analysis of tissue biomarkers and tissue and CNS cell fractionation for RNAseq profiling.
• Critical thinker with strong data analysis skills including application of statistics
• Excellent oral and written communication skills including target proposals and program updates in governance settings, manuscripts for publication in peer reviewed scientific journals.
• Strong working knowledge of primary neuronal and glia cell culture methods
• Working knowledge in the application of iPSC derived model systems in vitro and in vivo including cell transplantation
• Experience in designing and executing mouse behavioral studies.
Your role at Merck is integral to helping the world meet new breakthroughs that affect generations to come, and we're counting on your skills and inventiveness to help make meaningful contributions to global medical advancement. At Merck, we're inventing for life.
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