Senior Scientist Cell Line Development Job in New Jersey (NJ), Cell Biology, Biology, Research and Development Career, Full Time Jobs in Celgene Corporation
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Senior Scientist Cell Line Development job in Summit

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Celgene Corporation jobs
New Jersey (NJ), Summit
Job Code:  1801495
Employer:  Celgene Corporation
Category:  Cell Biology
Biology
Research and Development
Job Type:  Full Time

Location
Country:  United States
State:  New Jersey (NJ)
City:  Summit
Zip Code:  07901
09/13/2018

Description

Description
Celgene is a global biopharmaceutical company leading the way in medical innovation to help patients live longer, better lives. Our purpose as a company is to discover and develop therapies that will change the course of human health. We value our passion for patients, ​quest for innovation, spirit of independence and love of challenge. With a presence in more than 70 countries, and growing - we look for talented people to grow our business, advance our science and contribute to our unique culture.

Senior Scientist, Cell Line Development - Biologics
Summit, NJ
DEPARTMENT

Biologics Development and Manufacturing

PREREQUISITES

PhD in Biological Sciences, Molecular Biology, Biochemical Engineering, or relevant discipline with minimum 6 years of relevant industrial experience, MS with over 12 years of relevant experience.

This Senior Scientist position will lead internal cell line development activities, manage development projects with external partners and outsourcing activities, and support regulatory filing for both early and later stage programs.

Responsibilities will include, but are not limited to, the following:

Focusing on the development of mammalian cell lines for the production of monoclonal antibody and other complex recombinant proteins.
Performing key activities associated with production cell line development using established protein expression platform.
Developing and optimizing new protein expression platform to support fast to FIH development.
Understanding IP landscape of novel technologies in cell line development and developing a strategy to ensure freedom to operate.
Managing cell line development projects with external partners and outsourcing activities.
Managing tech transfer activities to support cell banking, cell bank testing, and drug substance manufacturing.
Working closely with discovery, upstream and downstream process development, as well as analytical development teams to support drug substance development of Celgene biologics pipeline.
Serving as SME to support cell line development in cross-functional CMC teams as well as author/review regulatory filings for early and late stage projects.
Writing technical reports and presenting data in internal meetings.
Supervising direct reports and providing mentorship to a growing team.
Skills/Knowledge Required:

Extensive experience with cell line development for production of monoclonal antibody, fusion proteins, bi-specific antibody and other complex recombinant proteins.
Extensive experience with all key activities for generating mammalian production cell lines, including transfection, selection, single cell cloning, high throughput screening, characterization of clonal cell lines using scale-down models, cell banking, and cell line stability studies.
Experience with DNA cloning, vector design and construction, and genetic characterization of production cell banks is required.
Experience with high throughput immunological assays such as Octet assay, ELISA, and FACS analysis.
Hands on experience with FACS Sorting will be a plus.
In-depth knowledge of antibody technology and protein expression as well as a good understanding of regulatory guidelines for human therapeutics.
The candidate must be well organized and have excellent oral and written communication skills
Demonstrated ability to think critically as well as possess excellent problem-solving skills.
To be able to perform well in cross-functional teams to meet project timelines.
#LI-POST

Celgene is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Celgene complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Celgene in the U.S.

ref: (1801495)
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