Senior Scientist/Associate Principal Scientist, Translational Genomics, Oncology job in Waltham
|Employer:|| AstraZeneca Pharmaceuticals|
|Category:||Research and Development|
Senior Scientist/Associate Principal Scientist, Translational Genomics, Oncology IMED, Waltham, MA. |
At AstraZeneca , we work together across global boundaries to make an impact and find answers to challenges. We do this with the utmost integrity even in the most difficult situations because we are committed to doing the right thing. We continuously forge partnerships that help pursue world-class medicines in new ways, combining our people's exceptional skills with those of people from all over the globe.
Oncology Translational Science Genomics Background
The Oncology IMED (Innovative Medicine and Early Discovery) Translational Science function exists to ensure effective and strategic biomarker studies for oncology project teams. Closely interacting with the pre-clinical iScience, Early Clinical Development, and Personalized Healthcare diagnostics functions, IMED Translational Science is the single point of accountability for delivery of robust, scientifically-driven biomarkers to all Oncology project teams, providing feasibility assessments, technical validation, centralized biomarker analysis capability for clinical samples, and early clinical phase engagement.
The Translational Genomics function leverages Next Generation Sequencing (NGS) and other advanced technologies to match the right patient to the right drug and support precision medicine approaches for the AZ Oncology pipeline.
Major Responsibilities and Accountabilities
You will be responsible for performing analysis work as part of a genomics lab - understanding the experiment and associated molecular, sample, and clinical data, collaborating with colleagues in Production Informatics and Bioinformatics, performing thoughtful analysis and interpretation of results, then documenting and communicating results to appropriate partners.
•Deliver analysed genomic information to AZ project teams and other partners through analysis of NGS and other leading-edge genetics/genomics technologies. NGS data includes internally generated data, NGS data from outsourcing companies, and data from collaborators and consortia
•The job role will focus on NGS analysis, but with lab biologist experience and perspective. The candidate will lead NGS analysis efforts, leveraging LIMS and lab analytics tools as well as genomic computational tools, and integrating sample and patient metadata. Output reports are focused on project needs to deliver technology development solutions (evaluations of platforms, vendors, and emerging technologies), mechanisms of drug response and resistance, and clinically qualified biomarkers that will guide dose selection, schedule, patient stratification and selection
•Perform data QC, trouble-shooting, determine reasons for outlier signal, assay noise and discordance; integrate QC, experimental, and sample/clinical metadata and look for associations; interpret results then develop and communicate a report in a timely manner to the project lead and/or project teams.
•Deliver biomarker assays and genomic/molecular profiling datasets in a high-throughput genomics lab, leveraging a LIMS system for sample tracking, Jira and other software tools for project progress, electronic lab notebooks for documentation, and written reports clearly and concisely summarizing results
•Where appropriate, work in collaboration with diagnostic, clinical, and regulatory partners to develop companion diagnostics
•For biomarker work, maintain appropriate documentation (data entry into electronic capture systems, including lab notebook), be compliant with internal and external requirements, assist in preparation of regulatory documents and responses to questions, and participate in external presentation of results and peer-reviewed journal publications
•Highly desired for candidate to have experience working in a regulated lab environment including compliance with CLIA, CAP, NY and FDA testing, demonstrated experience with quality control, quality assurance, writing and reviewing supporting documents, SOPs, validation plans, validation reports, and maintaining regulatory documents and paperwork
•M.S./Ph.D. in a relevant science subject
•5 years of experience for Senior Scientist; 7 years Associate Principal Scientist
•Prior experience with NGS, but role will focus on analysis of the NGS data, not the lab work (though there is the potential for some limited lab work by the candidate if needed)
•Experience with computational software for NGS analysis and data-mining. Experience with Unix, basic programming, use of R, and use of statistical packages desired but not required.
•Strong analytical skills, excellent oral and written communication skills, with clear documentation of work performed and ability to describe and understand its importance
•Excellent problem-solving skills with clear understanding of the balance of innovation, smart risks, and project delivery
•Good organizational and planning skills
•Good interpersonal skills and ability to multi-task project work
Reporting Relationship: Executive Director, Oncology Translational Genomics
AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialization of prescription medicines for some of the world's most serious diseases. But we're more than one of the world's leading pharmaceutical companies. At AstraZeneca, we're proud to have a unique workplace culture that inspires innovation and collaboration. Here, employees are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity.
Next Steps - Apply today!
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AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised