Postdoctoral Fellow (NCI) Job in Maryland (MD), Research and Development Career, Full Time Jobs in Leidos Biomedical Research, Inc.
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Postdoctoral Fellow (NCI) job in Frederick Md

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Leidos Biomedical Research, Inc. jobs
Maryland (MD), Frederick Md
Job Code:  660881
Employer:  Leidos Biomedical Research, Inc.
Category:  Research and Development
Job Type:  Full Time

Location
Country:  United States
State:  Maryland (MD)
City:  Frederick Md
10/11/2018

Description
Description

PROGRAM DESCRIPTION

LHRI - The Laboratory of Human Retrovirologyand Immunoinformatics (LHRI), Clinical Services Program, Applied/ DevelopmentalDirectorate, has investigated mechanisms multiple drug resistance (MDR) of HIVand innate immune response against HIV or HIV related virus infectioncollaborating with National Institute of Allergy and Infectious Diseases(NIAID).

To develop novel immune therapies for MDR-HIVor other virus-infected patients, LHRI has investigated anti-viral activity ofmultiple cytokine(s) and immune responses against virus infection, anddiscovered Interleukin (IL)-27 and IL-29 (Interferon-labmda1) as novel anti-HIVcytokines (Blood 2007, AIDS 2008, JICR2010, PlosOne 2013, Nuc.Acid.Res 2013), novel micro RNAs as anti-viral/tumoreRNAs (BBRC 2013, Sci.Rep 2018), Ku70 protein as a novel cytosolic DNA sensorthat induces a novel innate immune response ( J.I. 2011, Sci.Signal 2017). LHRIhas elucided SPTNBN1 as a host restriction factor for HIV infection (JEM 2013)and a novel cell signal pathways via non-coding small RNAs (Nuc.Acid.Res 2013).Currently LHRI has also developed a novel gene therapy to suppress virusreplication.

KEYROLES/RESPONSIBILITIES

Postdoctoral Fellow will:

  • Directly work with the Lab head and involve inthe development of novel gene therapies to suppress MDR-HIV or other virusreplication utilizing a combination of CRISPR/Case9 (or other gene editingmethods) and other protocols
  • Identify protein/gene that suppresses HIV orother virus infection using protein mass/gene micro array/NGS/2DIG and thencharacterize the mechanism of the inhibition
  • Publish paper(s) and present the findings ininternational or domestic scientific conference(s)


Qualifications

BASIC QUALIFICATIONS

To be considered forthis position, you must minimally meet the knowledge, skills, and abilitieslisted below:

  • Possession of a PhD or MD/PhD degree from anaccredited college or university according to the Council for Higher EducationAccreditation. (Additional qualifying experience may be substituted for therequired education). Foreign degrees must be evaluated for U.S. equivalency
  • No experience beyond the Doctorate degreerequired
  • Must be able to obtain and maintain a securityclearance


PREFERREDQUALIFICATIONS

Candidates with thesedesired skills will be given preferential consideration:

  • General molecular biology techniques (longRT-PCR, loning of genes, genomic DNA isolation, construction of expressionplasmids)
    • Tissue culture (cell lines and primary humancells:T cells, monocytes, NK cells,dendritic cells and macrophages)
    • DNA, RNA or protein transfection
    • Qrt-PCR
    • Flow cytometer analysis using Flow Joe
    • Western blotting
    • Immuno precipitation (pull down) assay
    • Native or recombinant protein isolation usingFPLC or HPLC
    • Alpha screening
    • Confocal microscopy
    • AMNIS
    • CRISPR technology
    • Protein mass and genechip assay
    • Handling of replication competent HIV virus andlentivirus
    • NGS analysis
    • Gel-shift (EMSA) assay


Expected Competencies:

  • Strong background in immunology or HIVvirology. The ability to challenge and establish new assay system(s)


Leidos is a global science and technology solutions leader working to solve the world's toughest challenges in the defense, intelligence, homeland security, civil, and health markets. The company's 33,000 employees support vital missions for government and commercial customers. Headquartered in Reston, Virginia, Leidos reported pro forma annual revenues of approximately $10 billion for the fiscal year ended January 1, 2016 after giving effect to the recently completed combination of Leidos with Lockheed Martin's Information Systems & Global Solutions business (IS&GS). For more information, visit www.Leidos.com. The company's diverse employees support vital missions for government and commercial customers. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. Leidos will consider qualified applicants with criminal histories for employment in accordance with relevant Laws. Leidos is an equal opportunity employer/disability/vet.
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