Research Associate III (NCI) Job in Maryland (MD), Research and Development Career, Full Time Jobs in Leidos Biomedical Research, Inc.
Sign in
Create a candidate account
Create a candidate account
Create an employer account
Sign in to an existing account
Create a candidate account
Create an employer account
Sign in to an existing account
Forgot password
Forgot password
Sign in
Create a candidate account
Sign in
Create an employer account

Research Associate III (NCI) job in Frederick Md

Sign in
Create a candidate account
Leidos Biomedical Research, Inc. jobs
Maryland (MD), Frederick Md
Job Code:  659693
Employer:  Leidos Biomedical Research, Inc.
Category:  Research and Development
Job Type:  Full Time

Country:  United States
State:  Maryland (MD)
City:  Frederick Md



The Clinical Pharmacodynamic Biomarkers Programis responsible for identification of biomarkers of response to new targetedagents entering clinical trials in the Developmental Therapeutics Program ofthe National Cancer Institute (NCI). The scope of work includes assay design,development, validation, fitness for purpose testing, transfer of assays toclinical laboratories, and clinical specimen analysis when required. PADISfacilitates mechanistic and performance analysis of putative anti-canceragents, diagnostic tests, and therapeutic interventions to clinicalapplications, including distinct molecular signatures for cancer, refinedmolecular assays, and state-of-the-art imaging techniques that are toohigh-risk for industry or academia to pursue.


The Research Associate III will:

  • Develop and implement multipleximmunofluorescence assays using confocal microscopy or whole slide imaging insupport of clinical studies and initiatives
  • Perform data analysis and present results fromimmunofluorescence assay studies on samples ranging from preclinical in vitrocell line experiments to fixed xenograft tissue sections to clinical specimenbiopsies
  • Design, test, and write detailed technicalstandard operating procedures (SOPs) for imaging and analysis for transfer toexternal labs
  • Generate materials and data necessary tosupport the primary experimental objectives of the program
  • Design, perform, analyze, and present in vitroexperiments to test pharmacodynamic marker responses to novel anti-cancertherapeutics in multiple formats, but particularly in multipleximmunofluorescence analysis of tissue based assays



To be considered forthis position, you must minimally meet the knowledge, skills, and abilitieslisted below:

  • Possession of a Bachelor's degree from anaccredited university according to the Council for Higher EducationAccreditation in a field related to biomedical research. (Additional qualifyingexperience may be substituted for the required education). Foreign degrees mustbe evaluated for U.S. equivalency.
  • In addition to the educational requirements, aminimum of eight (8) years of related work experience
  • Must be able to obtain and maintain a securityclearance
  • Demonstrated experience in cancer biology ordrug screening strategies is required
  • Outstanding English language and verbalcommunication skills are required. Ability to communicate with otherresearchers in a demanding scientific environment through presentations andpreparation of formal reports is essential.
  • Ability to maintain precise records
  • Experience with quantitative image analysissoftware (e.g., Definiens)
  • Experience with fluorescence widefield andconfocal microscopy
  • Ability to master novel technologies andinstrumentation in response to changes in project priorities or breakthroughtechnological innovations; hands-on instrumentation work is required for thisposition
  • Ability to follow, create and write detailedtechnical SOPs for imaging and analysis


Candidates with thesedesired skills will be given preferential consideration:

  • Experience with tissue-based immunofluorescenceassays.
  • Experience in the following areas: design andvalidation of multiplexed immunofluorescence assays; ability to work acrosstesting platforms during the assay development process.
  • Statistical analysis methods and software
  • Design of cell-based assays to test mechanismof action of candidate compounds
  • Background in oncology
  • Familiarity with GLP requirements, HIPAA, andHiTECH regulations

Expected Competencies:

  • High content image analysis; ConfocalMicroscopy; Cancer Biology

Leidos is a global science and technology solutions leader working to solve the world's toughest challenges in the defense, intelligence, homeland security, civil, and health markets. The company's 33,000 employees support vital missions for government and commercial customers. Headquartered in Reston, Virginia, Leidos reported pro forma annual revenues of approximately $10 billion for the fiscal year ended January 1, 2016 after giving effect to the recently completed combination of Leidos with Lockheed Martin's Information Systems & Global Solutions business (IS&GS). For more information, visit The company's diverse employees support vital missions for government and commercial customers. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status. Leidos will consider qualified applicants with criminal histories for employment in accordance with relevant Laws. Leidos is an equal opportunity employer/disability/vet.
ref: (659693)
Back to search results

Popular locations: New Jersey (NJ) (480) | Maryland (MD) (428) | Illinois (IL) (377) | Pennsylvania (PA) (245) | Texas (TX) (201) | California (CA) (156) | Massachusetts (MA) (137) | North Carolina (NC) (98) | Delaware (DE) (81) | Indiana (IN) (57)

Popular categories: Research and Development (595) | Sales (243) | Information Technology (185) | Operations (183) | Marketing (101) | Clinical Research (87) | Business Development (73) | Other (65) | Laboratory (63) | Finance (61)

Popular jobs: Director (493) | Manager (463) | Sales (313) | Associate Director (203) | Project Management (82) | Business Development (77) | Clinical Data Management (40) | Senior Specialist (40) | Bioinformatics Scientist (20) | Account Manager (14)